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KMID : 0388419990080020141
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Konkuk Journal of Medical Sciences
1999 Volume.8 No. 2 p.141 ~ p.148
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Immunohistochemical Study of Adenoid and Serum IgE in Otitis Media with Effusion
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Kang Sung-Ho
Kim Bo-Hyung
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Abstract
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Otitis media with effusion (OME) is one of the most common disease in children, but its pathogenesis is not clear. In particular the role of allergy has received conflicting support with widely varing opinions as to its importance. Recently, striking biochemical and immuno-chemical analytic techniques have opened a new approach in the study of OME. So we focused on distribution of IgE in the adenoid tissue and on serum. Authors compared the serum IgE and the distribution of IgE in adenoid tissue between the 20 patients underwent tonsillectomy, adenoidectomy and ventilating tube insertion and control group of 11 patients underwent tonsillectomy and adenoidectomy. The results were as follows ; 1) In the distribution of IgE in the adenoid tissue, there was a significant increase in the group of patients with OME compared to the control group(P<0.01). 2) In the analysis of serum IgE levels, although the levels of IgE in the OME patients and control group were higher than normal level, and the level of IgE in the OME patients was lower than that of control group, there was no significance(P>0.05).
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KEYWORD
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OME, IgE, allergy, immunofluorescence stain
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